Structure-Dependent Biological Activity of Racemic 1-Substituted 2-0-Hexadecylglycero-3- phosphocholines and Analogues
نویسندگان
چکیده
Phosphocholines, Platelet Stimulating Activity, Antiphytoviral Activity 1-substituted 2-0-hexadecylglycero-3-phosphocholines and some structural analogues were tested for their biological activity on two entirely different test systems: human thrombocytes and potato virus X in tobacco plants. Structural prerequisites for a high activity in both systems are the alkyl glyceryl ether structural element, a short-chain substituent in the C -l position, and the phosphocholine grouping. Accordingly, 1-O-methyl derivative (2) and 1-O-acetyl derivative (5) have the strongest effect on the biological activity o f both test systems. The intensity o f the effect of the tested compounds does not correlate with membranolytic properties measured by the lytic action on red cells.
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